Version 5.4
Bos taurus Gene: ARSA
Summary
InnateDB Gene IDBG-642822.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARSA
Gene Name Arylsulfatase A
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016053
Encoded Proteins
IDBP-695316
Arylsulfatase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100299:
The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:120152353-120155489
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021364 ENSBTAP00000021364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004098 cerebroside-sulfatase activity
GO:0005509 calcium ion binding
GO:0008484 sulfuric ester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0007339 binding of sperm to zona pellucida
GO:0008152 metabolic process
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100299
View Gene Order
ENSMUSG00000022620
View Gene Order
Pathways
NETPATH
REACTOME
REACT_204575
Glycosphingolipid metabolism pathway
REACT_208988
The activation of arylsulfatases pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_222556
Sphingolipid metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_206715
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121036
The activation of arylsulfatases pathway
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
REACT_111217
Metabolism pathway
REACT_198990
The activation of arylsulfatases pathway
REACT_199008
Glycosphingolipid metabolism pathway
REACT_188937
Metabolism pathway
REACT_245163
Sphingolipid metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_229541
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
hsa04142
Lysosome pathway
mmu00600
Sphingolipid metabolism pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.1076
RefSeq NM_001075205 XM_005207500
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca