Version 5.4
Bos taurus Gene: PGAP1
Summary
InnateDB Gene IDBG-642892.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGAP1
Gene Name GPI inositol-deacylase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020416
Encoded Proteins
IDBP-695401
post-GPI attachment to proteins 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197121:
PGAP1 catalyzes the inositol deacylation of glycosylphosphatidylinositol (GPI) at an early step in GPI biosynthesis. Inositol deacylation is essential for the generation of mature GPI capable of attachment to proteins (Tanaka et al., 2004 [PubMed 14734546]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:85835325-85909957
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027208 ENSBTAP00000027208
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0006505 GPI anchor metabolic process
GO:0006886 intracellular protein transport
GO:0007605 sensory perception of sound
GO:0009880 embryonic pattern specification
GO:0009948 anterior/posterior axis specification
GO:0021871 forebrain regionalization
GO:0060322 head development
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000197121
View Gene Order
ENSMUSG00000073678
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1830
Attachment of GPI anchor to uPAR pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
REACT_244576
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_236590
Attachment of GPI anchor to uPAR pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
mmu00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BNQ0
UniProt Splice Variant
Entrez Gene 504677
UniGene Bt.27795
RefSeq NM_001205550
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02005502 DAAA02005503 DAAA02005504
GenPept
RNA Seq Atlas 504677

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca