Version 5.4
Bos taurus Gene: BT.43859
Summary
InnateDB Gene IDBG-642960.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.43859
Gene Name acyl-coenzyme A thioesterase 8
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020371
Encoded Proteins
IDBP-695472
acyl-CoA thioesterase 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101473:
The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:75327439-75339408
Strand Forward strand
Band
Transcripts
ENSBTAT00000027152 ENSBTAP00000027152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0047617 acyl-CoA hydrolase activity
GO:0052815 medium-chain acyl-CoA hydrolase activity
Biological Process
GO:0006637 acyl-CoA metabolic process
GO:0016559 peroxisome fission
GO:0043649 dicarboxylic acid catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000101473
View Gene Order
ENSMUSG00000017307
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_17062
Beta-oxidation of very long chain fatty acids pathway
REACT_17017
Beta-oxidation of pristanoyl-CoA pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_121147
alpha-linolenic acid (ALA) metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_16957
Peroxisomal lipid metabolism pathway
REACT_121284
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_207530
Synthesis of bile acids and bile salts pathway
REACT_203193
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_196541
alpha-linolenic acid (ALA) metabolism pathway
REACT_247416
Beta-oxidation of very long chain fatty acids pathway
REACT_196529
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
REACT_243096
Beta-oxidation of pristanoyl-CoA pathway
REACT_246750
Peroxisomal lipid metabolism pathway
REACT_229469
Bile acid and bile salt metabolism pathway
KEGG
hsa00120
Primary bile acid biosynthesis pathway
hsa04146
Peroxisome pathway
mmu00120
Primary bile acid biosynthesis pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F6RWU6
UniProt Splice Variant
Entrez Gene 504360
UniGene Bt.43859
RefSeq NM_001075157
HUGO HGNC:15919
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036771
GenPept
RNA Seq Atlas 504360

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca