Version 5.4
Bos taurus Gene: PLTP
Summary
InnateDB Gene IDBG-642973.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLTP
Gene Name phospholipid transfer protein precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000559
Encoded Proteins
IDBP-695489
phospholipid transfer protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21787334
[Homo sapiens] PLTP may play a pivotal role in inflammation and innate immunity through its ability to accelerate the 'reverse LPS transport' pathway. (Demonstrated in mouse)
PMID 21787334
[Mus musculus] Pltp may play a pivotal role in inflammation and innate immunity through its ability to accelerate the 'reverse LPS transport' pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100979:
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:75374575-75384705
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000732 ENSBTAP00000000732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
Biological Process
GO:0010189 vitamin E biosynthetic process
GO:0030317 sperm motility
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100979
View Gene Order
ENSMUSG00000017754
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_213857
HDL-mediated lipid transport pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_211709
Lipoprotein metabolism pathway
KEGG
hsa03320
PPAR signaling pathway pathway
mmu03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.108851 Bt.34944
RefSeq NM_001035027 XM_005214558
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca