Version 5.4
Bos taurus Gene: JMJD6
Summary
InnateDB Gene IDBG-643020.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JMJD6
Gene Name Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Synonyms PTDSR
Species Bos taurus
Ensembl Gene ENSBTAG00000019153
Encoded Proteins
IDBP-695537
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26221041
[Homo sapiens] Reversible arginine methylation of TRAF6 is regulated by PRMT1 and JMJD6 and this in turn regulates TRAF6-dependent TLR signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070495:
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55675264-55681075
Strand Forward strand
Band
Transcripts
ENSBTAT00000025492 ENSBTAP00000025492
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0004872 receptor activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0033746 histone demethylase activity (H3-R2 specific)
GO:0033749 histone demethylase activity (H4-R3 specific)
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0070815 peptidyl-lysine 5-dioxygenase activity
Biological Process
GO:0001568 blood vessel development
GO:0001822 kidney development
GO:0002040 sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0007507 heart development
GO:0008380 RNA splicing
GO:0016568 chromatin modification
GO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0033077 T cell differentiation in thymus
GO:0042116 macrophage activation
GO:0043277 apoptotic cell clearance
GO:0043654 recognition of apoptotic cell
GO:0048024 regulation of mRNA splicing, via spliceosome
GO:0048821 erythrocyte development
GO:0055114 oxidation-reduction process
GO:0060041 retina development in camera-type eye
GO:0070078 histone H3-R2 demethylation
GO:0070079 histone H4-R3 demethylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000070495
View Gene Order
ENSMUSG00000056962
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.32358
RefSeq NM_001034320
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca