InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACOX1

Summary

InnateDB Gene

IDBG-643126.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACOX1

Gene Name

peroxisomal acyl-coenzyme A oxidase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030174

Encoded Proteins

IDBP-695657

peroxisomal acyl-coenzyme A oxidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161533:
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:56300413-56321456

Strand

Forward strand

Band

Transcripts

ENSBTAT00000029362

ENSBTAP00000029362

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0003997	acyl-CoA oxidase activity
GO:0005102	receptor binding
GO:0016401	palmitoyl-CoA oxidase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0030165	PDZ domain binding
GO:0047485	protein N-terminus binding
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006693	prostaglandin metabolic process
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0016559	peroxisome fission
GO:0019395	fatty acid oxidation
GO:0055088	lipid homeostasis
GO:0055114	oxidation-reduction process
GO:2000189	positive regulation of cholesterol homeostasis