InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RDH8

Summary

InnateDB Gene

IDBG-643148.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RDH8

Gene Name

Retinol dehydrogenase 8

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010188

Encoded Proteins

IDBP-695680

Retinol dehydrogenase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080511:
All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:15815879-15822349

Strand

Forward strand

Band

Transcripts

ENSBTAT00000013443

ENSBTAP00000013443

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004303	estradiol 17-beta-dehydrogenase activity
GO:0004745	retinol dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0052650	NADP-retinol dehydrogenase activity

Biological Process

GO:0006703	estrogen biosynthetic process
GO:0007601	visual perception
GO:0008152	metabolic process
GO:0042572	retinol metabolic process
GO:0050896	response to stimulus
GO:0055114	oxidation-reduction process