InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTPN1

Summary

InnateDB Gene

IDBG-643215.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN1

Gene Name

tyrosine-protein phosphatase non-receptor type 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006616

Encoded Proteins

IDBP-695758

tyrosine-protein phosphatase non-receptor type 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196396:
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:79263518-79324185

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008678

ENSBTAP00000008678

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0030971	receptor tyrosine kinase binding
GO:0044822	poly(A) RNA binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0008286	insulin receptor signaling pathway
GO:0009966	regulation of signal transduction
GO:0016311	dephosphorylation
GO:0030100	regulation of endocytosis
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031532	actin cytoskeleton reorganization
GO:0035791	platelet-derived growth factor receptor-beta signaling pathway
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway
GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity