Version 5.4
Bos taurus Gene: CDS1
Summary
InnateDB Gene IDBG-643256.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDS1
Gene Name Phosphatidate cytidylyltransferase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000045787
Encoded Proteins
IDBP-695803
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163624:
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:101195831-101270493
Strand Forward strand
Band
Transcripts
ENSBTAT00000065725 ENSBTAP00000055095
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004605 phosphatidate cytidylyltransferase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0016024 CDP-diacylglycerol biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163624
View Gene Order
ENSMUSG00000029330
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121000
Synthesis of PI pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_199010
Synthesis of PI pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
mmu00564
Glycerophospholipid metabolism pathway
mmu04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3MZU2
UniProt Splice Variant
Entrez Gene 100336936
UniGene
RefSeq XM_003586222
HUGO HGNC:1800
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018308 DAAA02018309 DAAA02018310 DAAA02018311
GenPept
RNA Seq Atlas 100336936
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca