Version 5.4
Bos taurus Gene: CDC37
Summary
InnateDB Gene IDBG-643270.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC37
Gene Name Hsp90 co-chaperone Cdc37
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011699
Encoded Proteins
IDBP-695816
cell division cycle 37 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105401:
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16154276-16158004
Strand Reverse strand
Band
Transcripts
ENSBTAT00000036173 ENSBTAP00000036036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 137 interaction(s) predicted by orthology.
Predicted by orthology
Total 137 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0031072 heat shock protein binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000105401
View Gene Order
ENSMUSG00000019471
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_115755
Signaling by ERBB2 pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_189085
Disease pathway
REACT_199123
Signaling by constitutively active EGFR pathway
REACT_188257
Signal Transduction pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL F1MHL1
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:1735
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019457 DAAA02019458 DAAA02019459
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca