InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDE4A

Summary

InnateDB Gene

IDBG-643271.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4A

Gene Name

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012032

Encoded Proteins

IDBP-695834

phosphodiesterase 4A

IDBP-695836

phosphodiesterase 4A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065989:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:16176856-16215655

Strand

Forward strand

Band

Transcripts

ENSBTAT00000015961	ENSBTAP00000015961
ENSBTAT00000015963	ENSBTAP00000015963

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007608	sensory perception of smell
GO:0008152	metabolic process
GO:0010738	regulation of protein kinase A signaling
GO:0035690	cellular response to drug
GO:0043949	regulation of cAMP-mediated signaling