Bos taurus Gene: KEAP1
Summary
InnateDB Gene IDBG-643288.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KEAP1
Gene Name kelch-like ECH-associated protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003543
Encoded Proteins
kelch-like ECH-associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Phosphorylation of Sqstm1 (p62) activates the Keap1-Nrf2 pathway during selective autophagy
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079999:
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16235815-16244046
Strand Reverse strand
Band
Transcripts
ENSBTAT00000004604 ENSBTAP00000004604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 73 interaction(s) predicted by orthology.
Predicted by orthology
Total 73 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0045604 regulation of epidermal cell differentiation
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005815 microtubule organizing center
GO:0030496 midbody
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
KEGG
Ubiquitin mediated proteolysis pathway
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
Oxidative stress induced gene expression via nrf2 [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL A7MBG4 Q0V8M8
UniProt Splice Variant
Entrez Gene 532791
UniGene Bt.2184
RefSeq NM_001101142 XM_005208764
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151545 BT026190 DAAA02019465
GenPept AAI51546 ABG67029
RNA Seq Atlas 532791
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)