Version 5.4
Bos taurus Gene: CYP24A1
Summary
InnateDB Gene IDBG-643291.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP24A1
Gene Name 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002765
Encoded Proteins
IDBP-695845
cytochrome P450, family 24, subfamily A, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000019186:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:82350503-82368773
Strand Reverse strand
Band
Transcripts
ENSBTAT00000003588 ENSBTAP00000003588
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0008403 25-hydroxycholecalciferol-24-hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0030342 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0033280 response to vitamin D
GO:0042359 vitamin D metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000019186
View Gene Order
ENSMUSG00000038567
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13523
Vitamin D (calciferol) metabolism pathway
REACT_13450
Vitamins pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
REACT_232159
Cytochrome P450 - arranged by substrate type pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_213027
Vitamins pathway
REACT_218811
Vitamin D (calciferol) metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_232343
Biological oxidations pathway
REACT_220061
Metabolism of steroid hormones and vitamin D pathway
KEGG
hsa00100
Steroid biosynthesis pathway
mmu00100
Steroid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BKM8
UniProt Splice Variant
Entrez Gene 540080
UniGene Bt.106031
RefSeq NM_001191417 XM_005214820
HUGO HGNC:2602
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036907
GenPept
RNA Seq Atlas 540080

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca