InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MBP

Summary

InnateDB Gene

IDBG-643421.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBP

Gene Name

myelin basic protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000022890

Encoded Proteins

IDBP-695975

myelin basic protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197971:
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:2558226-2590450

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002984

ENSBTAP00000002984

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0019911	structural constituent of myelin sheath

Biological Process

GO:0009636	response to toxic substance
GO:0021762	substantia nigra development
GO:0042552	myelination
GO:0061024	membrane organization

Cellular Component

GO:0033269	internode region of axon
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0043209	myelin sheath
GO:0071944	cell periphery

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000197971

View Gene Order

ENSMUSG00000041607

View Gene Order

Cross-References

SwissProt

TrEMBL

F6QBP1

UniProt Splice Variant

Entrez Gene

618684

UniGene

Bt.112099 Bt.64741

RefSeq

NM_001206674 XM_005223936

HUGO

HGNC:6925

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02056052

GenPept

RNA Seq Atlas

618684