InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RGS12

Summary

InnateDB Gene

IDBG-643518.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS12

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016714

Encoded Proteins

IDBP-696084

regulator of G-protein signaling 12

IDBP-696086

regulator of G-protein signaling 12

IDBP-696087

regulator of G-protein signaling 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159788:
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a member of the \'regulator of G protein signaling\' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:107286738-107325408

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022222	ENSBTAP00000022222
ENSBTAT00000065943	ENSBTAP00000055742
ENSBTAT00000065606	ENSBTAP00000054278

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0030695	GTPase regulator activity

Biological Process

GO:0007165	signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000159788

View Gene Order

ENSMUSG00000029101

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

INOH

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

XM_005208224 XM_581768

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas