Version 5.4
Bos taurus Gene: ECSIT
Summary
InnateDB Gene IDBG-643570.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECSIT
Gene Name Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015049
Encoded Proteins
IDBP-696131
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 10465784
[Homo sapiens] ECSIT is specific for the Toll/IL-1 pathways and is a regulator of MAP3K1 (MEKK1) processing.
PMID 25371197
[Homo sapiens] ECSIT binds to MAP3K7 and TRAF6 to form a complex that plays a pivotal role in activating TLR4-mediated NF-kB signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130159:
Gene Information
Type Protein coding
Genomic Location Chromosome 7:17085482-17097271
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020029 ENSBTAP00000020029
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0016651 oxidoreductase activity, acting on NAD(P)H
Biological Process
GO:0001707 mesoderm formation
GO:0002376 immune system process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030509 BMP signaling pathway
GO:0045087 innate immune response
GO:0051341 regulation of oxidoreductase activity
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000130159
View Gene Order
ENSMUSG00000066839
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_13
IL1 pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
INOH website
Toll-like receptor signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.2894
RefSeq NM_001034286
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca