InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BARD1

Summary

InnateDB Gene

IDBG-643630.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BARD1

Gene Name

BRCA1-associated RING domain protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000033690

Encoded Proteins

IDBP-696201

BRCA1 associated RING domain 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138376:
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq, Jul 2008]
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:103278272-103371020

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000047858

ENSBTAP00000045022

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 227 interaction(s) predicted by orthology.

Predicted by orthology
Total	227 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0042325	regulation of phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0046826	negative regulation of protein export from nucleus
GO:0085020	protein K6-linked ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0031436	BRCA1-BARD1 complex
GO:0043231	intracellular membrane-bounded organelle
GO:0070531	BRCA1-A complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000138376

View Gene Order

ENSMUSG00000026196

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

bard1pathway

BARD1 signaling events

Cross-References

SwissProt

TrEMBL

F1MAV4

UniProt Splice Variant

Entrez Gene

530961

UniGene

Bt.106375 Bt.89068

RefSeq

NM_001192701 XM_005202787

HUGO

HGNC:952

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02005860

GenPept

RNA Seq Atlas

530961