Version 5.4
| Bos taurus Gene: BT.29198 | |||||||||||||||||
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| Summary | |||||||||||||||||
| InnateDB Gene | IDBG-643703.3 | ||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
| Gene Symbol | BT.29198 | ||||||||||||||||
| Gene Name | meprin A subunit beta precursor | ||||||||||||||||
| Synonyms | |||||||||||||||||
| Species | Bos taurus | ||||||||||||||||
| Ensembl Gene | ENSBTAG00000020391 | ||||||||||||||||
| Encoded Proteins |
meprin A subunit beta
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| Protein Structure | |||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
| Entrez Gene | |||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141434:
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011] |
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| Gene Information | |||||||||||||||||
| Type | Protein coding | ||||||||||||||||
| Genomic Location | Chromosome 24:25292754-25328875 | ||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||
| Band | |||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||
| NETPATH | |||||||||||||||||
| REACTOME | |||||||||||||||||
| KEGG |
Protein digestion and absorption pathway
Protein digestion and absorption pathway
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| INOH | |||||||||||||||||
| PID NCI |
Posttranslational regulation of adherens junction stability and dissassembly
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| Cross-References | |||||||||||||||||
| SwissProt | |||||||||||||||||
| TrEMBL | E1B7B4 | ||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||
| Entrez Gene | 540701 | ||||||||||||||||
| UniGene | Bt.29198 | ||||||||||||||||
| RefSeq | NM_001144098 XM_005224011 XM_005224012 XM_005224013 | ||||||||||||||||
| HUGO | HGNC:7020 | ||||||||||||||||
| OMIM | |||||||||||||||||
| CCDS | |||||||||||||||||
| HPRD | |||||||||||||||||
| IMGT | |||||||||||||||||
| EMBL | DAAA02056449 DAAA02056450 | ||||||||||||||||
| GenPept | |||||||||||||||||
| RNA Seq Atlas | 540701 | ||||||||||||||||