InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AXIN2

Summary

InnateDB Gene

IDBG-643724.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AXIN2

Gene Name

axin-2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030162

Encoded Proteins

IDBP-696303

axin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168646:
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:62834850-62860774

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000042542

ENSBTAP00000040177

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0070411	I-SMAD binding

Biological Process

GO:0001756	somitogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0001957	intramembranous ossification
GO:0003139	secondary heart field specification
GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010942	positive regulation of cell death
GO:0030111	regulation of Wnt signaling pathway
GO:0030282	bone mineralization
GO:0032423	regulation of mismatch repair
GO:0034613	cellular protein localization
GO:0035414	negative regulation of catenin import into nucleus
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042476	odontogenesis
GO:0043570	maintenance of DNA repeat elements
GO:0045668	negative regulation of osteoblast differentiation
GO:0048255	mRNA stabilization
GO:0061181	regulation of chondrocyte development
GO:0070602	regulation of centromeric sister chromatid cohesion
GO:0090090	negative regulation of canonical Wnt signaling pathway