Version 5.4
Bos taurus Gene: DSG1
Summary
InnateDB Gene IDBG-643764.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSG1
Gene Name desmoglein-1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013831
Encoded Proteins
IDBP-696345
desmoglein-1 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134760:
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:26089489-26133405
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018382 ENSBTAP00000018382
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0045295 gamma-catenin binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0050821 protein stabilization
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134760
View Gene Order
ENSMUSG00000069441
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13579
Apoptotic cleavage of cell adhesion proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
REACT_258521
Apoptosis pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_212869
Apoptotic cleavage of cell adhesion proteins pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
hsa05150
Staphylococcus aureus infection pathway
mmu05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MIW8
UniProt Splice Variant
Entrez Gene 281131
UniGene Bt.161
RefSeq NM_174045
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02056458
GenPept
RNA Seq Atlas 281131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca