InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MAP4K2

Summary

InnateDB Gene

IDBG-643979.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP4K2

Gene Name

mitogen-activated protein kinase kinase kinase kinase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001037

Encoded Proteins

IDBP-696640

mitogen-activated protein kinase kinase kinase kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168067:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:43648614-43661350

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001378

ENSBTAP00000001378

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0006468	protein phosphorylation
GO:0006903	vesicle targeting
GO:0007257	activation of JUN kinase activity
GO:0016310	phosphorylation
GO:0035556	intracellular signal transduction
GO:0046330	positive regulation of JNK cascade