Version 5.4
Bos taurus Gene: NDRG1
Summary
InnateDB Gene IDBG-644056.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDRG1
Gene Name protein NDRG1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000711
Encoded Proteins
IDBP-696661
protein NDRG1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104419:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:9109762-9165926
Strand Forward strand
Band
Transcripts
ENSBTAT00000000950 ENSBTAP00000000950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0017137 Rab GTPase binding
GO:0043015 gamma-tubulin binding
GO:0045296 cadherin binding
Biological Process
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0032287 peripheral nervous system myelin maintenance
GO:0045576 mast cell activation
GO:0071456 cellular response to hypoxia
GO:0090232 positive regulation of spindle checkpoint
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0015630 microtubule cytoskeleton
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000104419
View Gene Order
ENSMUSG00000005125
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
myc_represspathway
Validated targets of C-MYC transcriptional repression
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL F1MS38
UniProt Splice Variant
Entrez Gene 504499
UniGene Bt.1537
RefSeq NM_001035009
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02037587
GenPept
RNA Seq Atlas 504499

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca