InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EPHA4

Summary

InnateDB Gene

IDBG-644137.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA4

Gene Name

ephrin type-A receptor 4 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010030

Encoded Proteins

IDBP-696760

ephrin receptor EphA4

IDBP-696762

ephrin receptor EphA4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116106:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:110251546-110405363

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000013238	ENSBTAP00000013238
ENSBTAT00000055480	ENSBTAP00000049507

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042731	PH domain binding
GO:0042802	identical protein binding
GO:0097161	DH domain binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0007628	adult walking behavior
GO:0008045	motor neuron axon guidance
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021957	corticospinal tract morphogenesis
GO:0032314	regulation of Rac GTPase activity
GO:0032317	regulation of Rap GTPase activity
GO:0043507	positive regulation of JUN kinase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048681	negative regulation of axon regeneration
GO:0048710	regulation of astrocyte differentiation
GO:0050770	regulation of axonogenesis
GO:0061001	regulation of dendritic spine morphogenesis
GO:0097155	fasciculation of sensory neuron axon
GO:0097156	fasciculation of motor neuron axon
GO:2001108	positive regulation of Rho guanyl-nucleotide exchange factor activity

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031901	early endosome membrane