InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KAT5

Summary

InnateDB Gene

IDBG-644226.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KAT5

Gene Name

histone acetyltransferase KAT5

Synonyms

HTATIP

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005578

Encoded Proteins

IDBP-696848

K(lysine) acetyltransferase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172977:
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:44544726-44552254

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007328

ENSBTAP00000007328

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 176 interaction(s) predicted by orthology.

Predicted by orthology
Total	176 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006302	double-strand break repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0010212	response to ionizing radiation
GO:0016573	histone acetylation
GO:0032703	negative regulation of interleukin-2 production
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0000812	Swr1 complex
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0032777	Piccolo NuA4 histone acetyltransferase complex
GO:0035267	NuA4 histone acetyltransferase complex