InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SCN5A

Summary

InnateDB Gene

IDBG-644339.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN5A

Gene Name

sodium channel protein type 5 subunit alpha

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009155

Encoded Proteins

IDBP-696980

sodium channel protein type 5 subunit alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25368329

[Homo sapiens] SCN5A is a novel pathogen sensor that initiates anti-viral signalling and transcription through ADCY8 and ATF2.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183873:
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:12015691-12118718

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012068

ENSBTAP00000012068

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086063	voltage-gated sodium channel activity involved in regulation of SA node cell action potential
GO:0097110	scaffold protein binding

Biological Process

GO:0003231	cardiac ventricle development
GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0014070	response to organic cyclic compound
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0086004	regulation of cardiac muscle cell contraction
GO:0086010	membrane depolarization during action potential
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086046	membrane depolarization involved in regulation of SA node cell action potential
GO:0086091	regulation of heart rate by cardiac conduction

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030315	T-tubule
GO:0034706	sodium channel complex