InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BRMS1

Summary

InnateDB Gene

IDBG-644383.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRMS1

Gene Name

Breast cancer metastasis-suppressor 1 homolog

Synonyms

BRMS1L

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017689

Encoded Proteins

IDBP-697017

Breast cancer metastasis-suppressor 1 homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174744:
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:45035736-45042778

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023526

ENSBTAP00000023526

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0009987	cellular process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090312	positive regulation of protein deacetylation
GO:2000210	positive regulation of anoikis