Version 5.4
Bos taurus Gene: SEH1L
Summary
InnateDB Gene IDBG-644494.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEH1L
Gene Name Nucleoporin SEH1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010792
Encoded Proteins
IDBP-697135
Nucleoporin SEH1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085415:
The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:43639269-43659101
Strand Forward strand
Band
Transcripts
ENSBTAT00000049050 ENSBTAP00000045994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002534 cytokine production involved in inflammatory response
GO:0006810 transport
GO:0006999 nuclear pore organization
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007080 mitotic metaphase plate congression
GO:0015031 protein transport
GO:0050830 defense response to Gram-positive bacterium
GO:0051028 mRNA transport
GO:0051301 cell division
GO:0051315 attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005694 chromosome
GO:0031080 nuclear pore outer ring
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000085415
View Gene Order
ENSMUSG00000079614
View Gene Order
Pathways
NETPATH
REACTOME
REACT_221274
Metabolism of carbohydrates pathway
REACT_222460
SLC-mediated transmembrane transport pathway
REACT_203892
Hexose transport pathway
REACT_216366
M Phase pathway
REACT_212887
Separation of Sister Chromatids pathway
REACT_201906
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_215084
Mitotic Metaphase and Anaphase pathway
REACT_219973
Myoclonic epilepsy of Lafora pathway
REACT_211185
Mitotic Anaphase pathway
REACT_209409
Nuclear Envelope Breakdown pathway
REACT_226022
Gene Expression pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_269816
Transcriptional regulation by small RNAs pathway
REACT_214934
Cell Cycle pathway
REACT_210324
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_204270
Glucose transport pathway
REACT_211129
Glycogen storage diseases pathway
REACT_219139
Metabolism pathway
REACT_211448
Mitotic Prophase pathway
REACT_209545
Resolution of Sister Chromatid Cohesion pathway
REACT_210892
Regulatory RNA pathways pathway
REACT_203101
Mitotic Prometaphase pathway
REACT_207087
Disease pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_196648
Nuclear Envelope Breakdown pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_189085
Disease pathway
REACT_196650
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_198961
Resolution of Sister Chromatid Cohesion pathway
REACT_204192
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
REACT_188804
Cell Cycle pathway
REACT_188937
Metabolism pathway
REACT_241408
M Phase pathway
REACT_270446
Transcriptional regulation by small RNAs pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_256756
Mitotic Prometaphase pathway
REACT_253543
Glucose transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_240125
Hexose transport pathway
REACT_203949
Glycogen storage diseases pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_250557
Mitotic Prophase pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_202512
Mitotic Anaphase pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
hsa03013
RNA transport pathway
mmu03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.103393 Bt.71586
RefSeq NM_001103089
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca