InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.79817

Summary

InnateDB Gene

IDBG-644624.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.79817

Gene Name

von Hippel-Lindau disease tumor suppressor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016101

Encoded Proteins

IDBP-697271

von Hippel-Lindau disease tumor suppressor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134086:
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:16760055-16764930

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000030804

ENSBTAP00000030774

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 340 interaction(s) predicted by orthology.

Predicted by orthology
Total	340 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0032403	protein complex binding

Biological Process

GO:0001525	angiogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0010498	proteasomal protein catabolic process
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0030198	extracellular matrix organization
GO:0043534	blood vessel endothelial cell migration
GO:0045893	positive regulation of transcription, DNA-templated
GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070243	regulation of thymocyte apoptotic process
GO:0070244	negative regulation of thymocyte apoptotic process
GO:2001233	regulation of apoptotic signaling pathway