Version 5.4
Bos taurus Gene: ADRBK1
Summary
InnateDB Gene IDBG-644669.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRBK1
Gene Name Beta-adrenergic receptor kinase 1
Synonyms GRK2
Species Bos taurus
Ensembl Gene ENSBTAG00000005832
Encoded Proteins
IDBP-697326
Beta-adrenergic receptor kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24755316
[Mus musculus] Fibrates protect against bacteria�induced sepsis by inhibiting LPS�mediated ERK phosphorylation and the expression of Adrbk1 (GRK2), thereby preventing Cxcr2 down-regulation on neutrophils.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000173020:
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:45844928-45852607
Strand Forward strand
Band
Transcripts
ENSBTAT00000055962 ENSBTAP00000050806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031694 alpha-2A adrenergic receptor binding
GO:0031755 Edg-2 lysophosphatidic acid receptor binding
GO:0047696 beta-adrenergic receptor kinase activity
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway
GO:0002031 G-protein coupled receptor internalization
GO:0003108 negative regulation of the force of heart contraction by chemical signal
GO:0006468 protein phosphorylation
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0007507 heart development
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009966 regulation of signal transduction
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0031623 receptor internalization
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0045988 negative regulation of striated muscle contraction
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000173020
View Gene Order
ENSMUSG00000024858
View Gene Order
Pathways
NETPATH
REACTOME
REACT_217956
DAP12 interactions pathway
REACT_208036
Signaling by EGFR pathway
REACT_204121
PLCG1 events in ERBB2 signaling pathway
REACT_205036
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_205369
Signaling by GPCR pathway
REACT_204365
Signaling by PDGF pathway
REACT_202422
Calmodulin induced events pathway
REACT_213902
DAG and IP3 signaling pathway
REACT_216844
PLC-gamma1 signalling pathway
REACT_202837
Signaling by FGFR pathway
REACT_213138
Immune System pathway
REACT_204754
EGFR interacts with phospholipase C-gamma pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_214353
Signal Transduction pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_211557
G-protein mediated events pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_209521
G alpha (q) signalling events pathway
REACT_214436
GPCR downstream signaling pathway
REACT_213422
PLC beta mediated events pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_207066
Signalling by NGF pathway
REACT_202198
Phospholipase C-mediated cascade pathway
REACT_212750
Downstream signal transduction pathway
REACT_219672
Opioid Signalling pathway
REACT_216714
Innate Immune System pathway
REACT_223374
Ca-dependent events pathway
REACT_216082
CaM pathway pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_203736
Signaling by FGFR in disease pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_10
Hedgehog pathway
NetPath_25
FSH pathway
REACTOME
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_15526
G-protein mediated events pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_15307
Ca-dependent events pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_188190
PLCG1 events in ERBB2 signaling pathway
REACT_223625
GPCR downstream signaling pathway
REACT_189085
Disease pathway
REACT_254215
Signaling by GPCR pathway
REACT_259326
Ca-dependent events pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188573
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_263607
PLC-gamma1 signalling pathway
REACT_230745
Immune System pathway
REACT_236516
EGFR interacts with phospholipase C-gamma pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_240702
CaM pathway pathway
REACT_242976
Signaling by EGFR pathway
REACT_230708
Phospholipase C-mediated cascade pathway
REACT_248921
Signalling by NGF pathway
REACT_263353
Signaling by PDGF pathway
REACT_188269
DAG and IP3 signaling pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_207651
G alpha (q) signalling events pathway
REACT_242845
Opioid Signalling pathway
REACT_215587
Calmodulin induced events pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_253342
PLC beta mediated events pathway
REACT_248370
G-protein mediated events pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
mmu04062
Chemokine signaling pathway pathway
mmu04144
Endocytosis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
Hedgehog signaling pathway pathway
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
hdac_classii_pathway
Signaling events mediated by HDAC Class II
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
Cross-References
SwissProt P21146
TrEMBL F1N7J3
UniProt Splice Variant
Entrez Gene 282682
UniGene Bt.4693
RefSeq NM_174710
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02063609 M34019
GenPept AAA30384
RNA Seq Atlas 282682

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca