Version 5.4
Bos taurus Gene: CHKA
Summary
InnateDB Gene IDBG-644844.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHKA
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010304
Encoded Proteins
IDBP-697518
choline kinase alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110721:
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:46225620-46257618
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013607 ENSBTAP00000013607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004103 choline kinase activity
GO:0004104 cholinesterase activity
GO:0004305 ethanolamine kinase activity
GO:0008144 drug binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0006656 phosphatidylcholine biosynthetic process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000110721
View Gene Order
ENSMUSG00000024843
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121238
Synthesis of PC pathway
REACT_120919
Synthesis of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_199009
Synthesis of PE pathway
REACT_207335
Synthesis of PC pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
mmu00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MI39
UniProt Splice Variant
Entrez Gene 514865
UniGene Bt.45241
RefSeq XM_002699402 XM_869433
HUGO HGNC:1937
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02063631
GenPept
RNA Seq Atlas 514865

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca