Version 5.4
Bos taurus Gene: MEGF10
Summary
InnateDB Gene IDBG-644881.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEGF10
Gene Name multiple EGF-like-domains 10
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000329
Encoded Proteins
IDBP-697557
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145794:
This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27820355-27998816
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000434 ENSBTAP00000000434
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0014719 satellite cell activation
GO:0014816 satellite cell differentiation
GO:0014841 satellite cell proliferation
GO:0034109 homotypic cell-cell adhesion
GO:0043654 recognition of apoptotic cell
GO:0048641 regulation of skeletal muscle tissue development
GO:0051147 regulation of muscle cell differentiation
GO:0055001 muscle cell development
Cellular Component
GO:0001891 phagocytic cup
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000145794
View Gene Order
ENSMUSG00000024593
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.111158 Bt.64852 Bt.68694
RefSeq NM_001046451 XM_005209094 XM_005209095 XM_005209096
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca