Bos taurus Gene: BT.17939
Summary
InnateDB Gene IDBG-644901.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.17939
Gene Name lamin-B1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002882
Encoded Proteins
lamin-B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113368:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:28414756-28465352
Strand Reverse strand
Band
Transcripts
ENSBTAT00000052423 ENSBTAP00000052689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0043274 phospholipase binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0005638 lamin filament
GO:0005654 nucleoplasm
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
TSLP pathway
REACTOME
Apoptotic execution phase pathway
Cellular responses to stress pathway
Initiation of Nuclear Envelope Reformation pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
Meiotic synapsis pathway
Apoptosis pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Apoptotic cleavage of cellular proteins pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
Mitotic Prophase pathway
Nuclear Envelope Reassembly pathway
Breakdown of the nuclear lamina pathway
Cell Cycle, Mitotic pathway
Meiosis pathway
Depolymerisation of the Nuclear Lamina pathway
Nuclear Envelope Breakdown pathway
Clearance of Nuclear Envelope Membranes from Chromatin pathway
Mitotic Metaphase and Anaphase pathway
Apoptosis pathway
Mus musculus biological processes pathway
Breakdown of the nuclear lamina pathway
Cellular responses to stress pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Apoptotic cleavage of cellular proteins pathway
Meiotic synapsis pathway
Cell Cycle pathway
Cellular Senescence pathway
Meiotic Synapsis pathway
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
Meiosis pathway
Apoptotic execution phase pathway
KEGG
INOH
PID BIOCARTA
Tnfr1 signaling pathway [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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