Version 5.4
Bos taurus Gene: PPP1R8
Summary
InnateDB Gene IDBG-644998.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R8
Gene Name nuclear inhibitor of protein phosphatase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003866
Encoded Proteins
IDBP-697675
nuclear inhibitor of protein phosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117751:
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:126111731-126129768
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005043 ENSBTAP00000005043
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008599 protein phosphatase type 1 regulator activity
Biological Process
GO:0008283 cell proliferation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000117751
View Gene Order
ENSMUSG00000028882
View Gene Order
Cross-References
SwissProt
TrEMBL A4FUE1
UniProt Splice Variant
Entrez Gene 282319
UniGene Bt.22
RefSeq NM_174582
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114750 DAAA02006344
GenPept AAI14751
RNA Seq Atlas 282319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca