InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HMGCR

Summary

InnateDB Gene

IDBG-645081.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGCR

Gene Name

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Synonyms

hmg-coa-r

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007840

Encoded Proteins

IDBP-697761

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113161:
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:6692478-6713106

Strand

Forward strand

Band

Transcripts

ENSBTAT00000010315

ENSBTAP00000010315

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042282	hydroxymethylglutaryl-CoA reductase activity
GO:0050661	NADP binding
GO:0050662	coenzyme binding
GO:0070402	NADPH binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006694	steroid biosynthetic process
GO:0006695	cholesterol biosynthetic process
GO:0008202	steroid metabolic process
GO:0008203	cholesterol metabolic process
GO:0008299	isoprenoid biosynthetic process
GO:0008542	visual learning
GO:0015936	coenzyme A metabolic process
GO:0016126	sterol biosynthetic process
GO:0043407	negative regulation of MAP kinase activity
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane