InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: STK3

Summary

InnateDB Gene

IDBG-645151.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STK3

Gene Name

serine/threonine-protein kinase 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000026234

Encoded Proteins

IDBP-697834

serine/threonine-protein kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104375:
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:67677676-67987801

Strand

Forward strand

Band

Transcripts

ENSBTAT00000037202

ENSBTAP00000037040

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001841	neural tube formation
GO:0003157	endocardium development
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007417	central nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0016310	phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0035329	hippo signaling
GO:0035556	intracellular signal transduction
GO:0046330	positive regulation of JNK cascade
GO:0046621	negative regulation of organ growth
GO:0051897	positive regulation of protein kinase B signaling
GO:0060215	primitive hemopoiesis
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0097284	hepatocyte apoptotic process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000104375

View Gene Order

ENSMUSG00000022329

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118607

Signaling by Hippo pathway

REACT_111102

Signal Transduction pathway

REACT_196537

Signaling by Hippo pathway

REACT_188257

Signal Transduction pathway

KEGG

hsa04010

MAPK signaling pathway pathway

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.64837

RefSeq

NM_001079607 XM_005215621

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas