Version 5.4
Bos taurus Gene: BT.27443
Summary
InnateDB Gene IDBG-645160.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.27443
Gene Name solute carrier family 22 member 18
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012742
Encoded Proteins
IDBP-697870
solute carrier family 22 member 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110628:
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms\' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:49332572-49351638
Strand Reverse strand
Band
Transcripts
ENSBTAT00000016935 ENSBTAP00000016935
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015238 drug transmembrane transporter activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006855 drug transmembrane transport
GO:0015893 drug transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000110628
View Gene Order
ENSMUSG00000000154
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22357
Organic cation transport pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22345
Organic cation/anion/zwitterion transport pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_198609
Organic cation/anion/zwitterion transport pathway
REACT_198610
Organic cation transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MWZ2
UniProt Splice Variant
Entrez Gene 504885
UniGene Bt.27443
RefSeq NM_001083374 XM_005227306 XM_005227307 XM_005227308
HUGO HGNC:10964
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02063706 DAAA02063707
GenPept
RNA Seq Atlas 504885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca