Version 5.4
Bos taurus Gene: ASCL2
Summary
InnateDB Gene IDBG-645227.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASCL2
Gene Name Achaete-scute homolog 2
Synonyms MASH2
Species Bos taurus
Ensembl Gene ENSBTAG00000026769
Encoded Proteins
IDBP-697917
Achaete-scute homolog 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183734:
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5\'-CANNTG-3\'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:49955760-49957635
Strand Forward strand
Band
Transcripts
ENSBTAT00000038236 ENSBTAP00000038051
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0030154 cell differentiation
GO:0035019 somatic stem cell maintenance
GO:0060708 spongiotrophoblast differentiation
GO:0060712 spongiotrophoblast layer development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000183734
View Gene Order
ENSMUSG00000009248
View Gene Order
Cross-References
SwissProt Q2EGB9
TrEMBL
UniProt Splice Variant
Entrez Gene 664650
UniGene Bt.46181
RefSeq NM_001040607
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116068 DQ333219 DQ381723
GenPept AAI16069 ABC49786 ABD39719
RNA Seq Atlas 664650

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca