Version 5.4
Bos taurus Gene: TMEM67
Summary
InnateDB Gene IDBG-645286.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM67
Gene Name Meckelin precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000044190
Encoded Proteins
IDBP-697992
transmembrane protein 67
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164953:
The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:72788487-72816854
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061587 ENSBTAP00000053764
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031005 filamin binding
GO:0051082 unfolded protein binding
Biological Process
GO:0010826 negative regulation of centrosome duplication
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0042384 cilium assembly
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005813 centrosome
GO:0030659 cytoplasmic vesicle membrane
GO:0036038 TCTN-B9D complex
GO:0060170 ciliary membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000164953
View Gene Order
ENSMUSG00000049488
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.26745
RefSeq NM_001205299
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca