InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DDX41

Summary

InnateDB Gene

IDBG-645290.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX41

Gene Name

probable ATP-dependent RNA helicase DDX41

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015187

Encoded Proteins

IDBP-697994

probable ATP-dependent RNA helicase DDX41

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21892174

[Homo sapiens] DDX41 is a helicase responsible for sensing intracellular DNA in myeloid dendritic cells. DDX41 expression knockdown blocked the induction of type I interferon and cytokine responses to DNA and DNA viruses. (Demonstrated in mice)

PMID 21892174

[Mus musculus] Ddx41 is a helicase responsible for sensing intracellular DNA in myeloid dendritic cells. Ddx41 expression knockdown blocked the induction of type I interferon and cytokine responses to DNA and DNA viruses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183258:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:40369423-40374999

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000043510

ENSBTAP00000041074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0008152	metabolic process
GO:0035458	cellular response to interferon-beta
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus