Version 5.4
Bos taurus Gene: HESX1
Summary
InnateDB Gene IDBG-645320.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HESX1
Gene Name homeobox expressed in ES cells 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001439
Encoded Proteins
IDBP-698021
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163666:
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:44449109-44450787
Strand Forward strand
Band
Transcripts
ENSBTAT00000001886 ENSBTAP00000001886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0043565 sequence-specific DNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007420 brain development
GO:0030916 otic vesicle formation
GO:0043584 nose development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048853 forebrain morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163666
View Gene Order
ENSMUSG00000040726
View Gene Order
Cross-References
SwissProt
TrEMBL B8YG98 B8YG99 C1IHU6 C1IHU7 F1MPM0 I3PWW7
UniProt Splice Variant
Entrez Gene 781811
UniGene
RefSeq NM_001191140 XM_005222946 XM_005222948
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054314 EU583494 EU583495 FJ529697 FJ529698 JF919676 JQ711178
GenPept ACE95862 ACE95863 ACL68084 ACL68085 AFI43814 AFN44372
RNA Seq Atlas 781811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca