Version 5.4
Bos taurus Gene: CLK4
Summary
InnateDB Gene IDBG-645344.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLK4
Gene Name dual specificity protein kinase CLK4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019414
Encoded Proteins
IDBP-698049
CDC-like kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113240:
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:41100796-41122562
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025863 ENSBTAP00000025863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043484 regulation of RNA splicing
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113240
View Gene Order
ENSMUSG00000020385
View Gene Order
Cross-References
SwissProt
TrEMBL E1B9M6
UniProt Splice Variant
Entrez Gene 529633
UniGene Bt.93357
RefSeq NM_001192988 XM_005209194 XM_005209195 XM_005209197
HUGO HGNC:13659
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020071
GenPept
RNA Seq Atlas 101909131 529633

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca