Version 5.4
Bos taurus Gene: PIDD
Summary
InnateDB Gene IDBG-645530.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIDD
Gene Name p53-induced protein with a death domain
Synonyms LRDD
Species Bos taurus
Ensembl Gene ENSBTAG00000019634
Encoded Proteins
IDBP-698239
p53-induced death domain protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177595:
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:50774018-50779315
Strand Forward strand
Band
Transcripts
ENSBTAT00000026157 ENSBTAP00000026157
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165 signal transduction
GO:0043066 negative regulation of apoptotic process
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000177595
View Gene Order
ENSMUSG00000025507
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
mmu04115
p53 signaling pathway pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL G5E5N0
UniProt Splice Variant
Entrez Gene 100137737
UniGene Bt.77807
RefSeq NM_001191487 XM_005227258 XM_005227259 XM_005227260 XM_005227261 XM_005227262
HUGO HGNC:16491
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02063757
GenPept
RNA Seq Atlas 100137737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca