Version 5.4
Bos taurus Gene: STAB1
Summary
InnateDB Gene IDBG-645561.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAB1
Gene Name stabilin-1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014782
Encoded Proteins
IDBP-698296
stabilin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010327:
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:48884238-48909562
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019663 ENSBTAP00000019663
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005041 low-density lipoprotein receptor activity
GO:0005044 scavenger receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005540 hyaluronic acid binding
GO:0030169 low-density lipoprotein particle binding
Biological Process
GO:0007155 cell adhesion
GO:0007267 cell-cell signaling
GO:0016525 negative regulation of angiogenesis
GO:0042742 defense response to bacterium
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000010327
View Gene Order
ENSMUSG00000042286
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_164002
Scavenging by Class H Receptors pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BNJ1
UniProt Splice Variant
Entrez Gene 505543
UniGene Bt.109029 Bt.53716
RefSeq NM_001205570
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054369
GenPept
RNA Seq Atlas 505543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca