InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNNC1

Summary

InnateDB Gene

IDBG-645587.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNNC1

Gene Name

Troponin C, slow skeletal and cardiac muscles

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000045757

Encoded Proteins

IDBP-698307

Troponin C, slow skeletal and cardiac muscles

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114854:
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:48988984-48991875

Strand

Forward strand

Band

Transcripts

ENSBTAT00000062950

ENSBTAP00000055780

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0031013	troponin I binding
GO:0031014	troponin T binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0051015	actin filament binding

Biological Process

GO:0006937	regulation of muscle contraction
GO:0032972	regulation of muscle filament sliding speed
GO:0043462	regulation of ATPase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction