InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CHMP4C

Summary

InnateDB Gene

IDBG-645613.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHMP4C

Gene Name

charged multivesicular body protein 4c

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004792

Encoded Proteins

IDBP-698331

charged multivesicular body protein 4C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164695:
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:83201749-83231069

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006291

ENSBTAP00000006291

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007034	vacuolar transport
GO:0009838	abscission
GO:0015031	protein transport
GO:0031565	cytokinesis checkpoint
GO:0032466	negative regulation of cytokinesis
GO:0050792	regulation of viral process
GO:1902188	positive regulation of viral release from host cell