InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TAF2

Summary

InnateDB Gene

IDBG-645634.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF2

Gene Name

transcription initiation factor TFIID subunit 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015333

Encoded Proteins

IDBP-698375

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064313:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:83552370-83639183

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061330

ENSBTAP00000053499

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006508	proteolysis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter