Version 5.4
Bos taurus Gene: BT.84824
Summary
InnateDB Gene IDBG-645684.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.84824
Gene Name calcium-dependent phospholipase A2 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000039122
Encoded Proteins
IDBP-698416
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127472:
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:133224531-133246491
Strand Reverse strand
Band
Transcripts
ENSBTAT00000052261 ENSBTAP00000050206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000127472
View Gene Order
ENSMUSG00000041193
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120829
Acyl chain remodelling of PC pathway
REACT_120722
Acyl chain remodelling of PI pathway
REACT_121384
Acyl chain remodelling of PS pathway
REACT_120906
Synthesis of PA pathway
REACT_121324
Acyl chain remodelling of PG pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa00590
Arachidonic acid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04975
Fat digestion and absorption pathway
hsa04972
Pancreatic secretion pathway
mmu00564
Glycerophospholipid metabolism pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu00591
Linoleic acid metabolism pathway
mmu00592
alpha-Linolenic acid metabolism pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu04972
Pancreatic secretion pathway
mmu04975
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.84824
RefSeq NM_001193052 XM_005203240 XM_005203241 XM_005203242
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca