InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PCK2

Summary

InnateDB Gene

IDBG-645758.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCK2

Gene Name

phosphoenolpyruvate carboxykinase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011934

Encoded Proteins

IDBP-698505

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100889:
This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:20870284-20878569

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015834

ENSBTAP00000015834

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004611	phosphoenolpyruvate carboxykinase activity
GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0017076	purine nucleotide binding