Version 5.4
Bos taurus Gene: BT.56096
Summary
InnateDB Gene IDBG-645805.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.56096
Gene Name ras association domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020963
Encoded Proteins
IDBP-698558
ras association domain-containing protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068028:
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50580394-50586504
Strand Forward strand
Band
Transcripts
ENSBTAT00000027919 ENSBTAP00000027919
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0031398 positive regulation of protein ubiquitination
GO:0050821 protein stabilization
GO:0071157 negative regulation of cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000068028
View Gene Order
ENSMUSG00000010067
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa05219
Bladder cancer pathway
hsa05200
Pathways in cancer pathway
mmu05219
Bladder cancer pathway
mmu05223
Non-small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt
TrEMBL F1MC29
UniProt Splice Variant
Entrez Gene 510276
UniGene Bt.56096
RefSeq NM_001075442
HUGO HGNC:9882
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054410
GenPept
RNA Seq Atlas 510276

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca