Version 5.4
Bos taurus Gene: PADI2
Summary
InnateDB Gene IDBG-645810.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PADI2
Gene Name protein-arginine deiminase type-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003403
Encoded Proteins
IDBP-698576
peptidyl arginine deiminase, type II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117115:
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:136049644-136103406
Strand Forward strand
Band
Transcripts
ENSBTAT00000004411 ENSBTAP00000004411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0030331 estrogen receptor binding
Biological Process
GO:0006464 cellular protein modification process
GO:0010848 regulation of chromatin disassembly
GO:0018101 protein citrullination
GO:0021762 substantia nigra development
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0036413 histone H3-R26 citrullination
GO:0048096 chromatin-mediated maintenance of transcription
GO:0070100 negative regulation of chemokine-mediated signaling pathway
GO:1901624 negative regulation of lymphocyte chemotaxis
Cellular Component
GO:0005737 cytoplasm
GO:0035327 transcriptionally active chromatin
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000117115
View Gene Order
ENSMUSG00000028927
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_005203269
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca